A 63-year-old man with a 45 pack-year smoking history presents with nephrotic syndrome. Vital signs show BP 142/88 mmHg, HR 88/min, RR 16/min, temperature 37.2°C, and SpO2 98% on room air. He reports unintentional 8-kg weight loss over 2 months and denies fever. Serum albumin is 2.1 g/dL. Renal biopsy demonstrates diffuse capillary wall thickening with granular subepithelial immune deposits. Which underlying condition most likely explains this renal pathology?
- A)Lung carcinomaGABARITO
- B)Polycystic kidney disease
- C)Renal cell carcinoma
- D)Acute pyelonephritis
- E)Analgesic nephropathy
Explicação
Membranous nephropathy can be secondary to solid tumors, especially lung or colon cancer, as well as hepatitis B, NSAIDs, and SLE. In an older smoker with weight loss and nephrotic syndrome, an underlying lung carcinoma is a classic association. Ver explicação completa e trilha adaptativa →