A 52-year-old man with a 20-pack-year smoking history and hyperlipidemia presents to the emergency department after experiencing two episodes of right-sided facial droop and arm weakness over the past week. Each episode lasted 18 minutes and resolved completely. He denies headache, vision changes, or speech difficulties. Vital signs are BP 158/92 mmHg, HR 78/min, temperature 37°C. Neurologic examination is now normal. Carotid duplex ultrasound shows 70% stenosis of the left internal carotid artery with peak systolic velocity of 230 cm/s. Laboratory values include LDL cholesterol 180 mg/dL, triglycerides 145 mg/dL, and fasting glucose 102 mg/dL. MRI brain with diffusion-weighted imaging shows no acute infarction. Which of the following is the most appropriate next step in management?
- A)Initiate aspirin 81 mg daily and high-intensity statin therapy with repeat carotid imaging in 3 months
- B)Start warfarin with target INR 2-3 for cardioembolic stroke prevention
- C)Perform carotid endarterectomy within 2 weeksGABARITO
- D)Refer for carotid artery angioplasty and stenting as an alternative to surgery
- E)Administer intravenous alteplase followed by heparin infusion
Explicação
This patient has symptomatic carotid stenosis (≥70%) with recent TIAs in the territory of the stenosed vessel. The NASCET trial established that carotid endarterectomy reduces stroke risk from 26% to 9% over 2 years in symptomatic patients with ≥70% stenosis w... Ver explicação completa e trilha adaptativa →