A 4-year-old boy presents to the emergency department after ingesting multiple tablets from his grandfather's pill organizer. He is lethargic with BP 70/45 mmHg, HR 42 bpm, RR 18, and normal temperature. ECG demonstrates sinus bradycardia. Serum glucose is normal. He denies ingestion of other substances. Which of the following is the best pharmacologic agent to improve cardiac contractility and heart rate in this acute overdose setting?
- A)Physostigmine
- B)Flumazenil
- C)Naloxone
- D)Methacholine
- E)GlucagonGABARITO
Explicação
Beta blocker overdose causes bradycardia, hypotension, and decreased contractility. Glucagon bypasses the blocked beta receptor by directly activating adenylate cyclase through its own receptor, increasing cAMP in cardiac myocytes and improving heart rate and ... Ver explicação completa e trilha adaptativa →