A 12-year-old male has a particular genetic disease. His mother is a carrier of the mutated gene, but his father is not clinically affected and is not a carrier. The patient has 4 siblings: a sister and a brother who are not clinically affected and are not carriers; a sister who is a carrier but is not clinically affected; and a brother who is clinically affected. This inheritance pattern is most consistent with which of the following diseases?

1. A)Tay-Sachs disease
2. B)Phenylketonuria
3. C)Cystic fibrosis
4. D)Alpha1-antitrypsin deficiency
5. E)Duchenne muscular dystrophyGABARITO