A 19-year-old man develops muscle rigidity and high fever shortly after induction of general anesthesia with sevoflurane and succinylcholine. Vital signs show temperature 39.2°C, heart rate 142/min, blood pressure 158/92 mmHg, respiratory rate 28/min, and SpO2 92% on supplemental oxygen. Arterial blood gas reveals pH 7.25 with PaCO2 58 mmHg. Serum creatinine kinase is markedly elevated at 8,500 U/L. Urine myoglobin is positive. Recent medication history is unremarkable. Which of the following is the most appropriate treatment?
- A)Pralidoxime
- B)DantroleneGABARITO
- C)Atropine
- D)Naloxone
- E)Methylene blue
Explicação
Malignant hyperthermia is due to abnormal ryanodine receptor mediated calcium release in skeletal muscle, triggered by volatile anesthetics or succinylcholine. Dantrolene treats it by inhibiting calcium release from the sarcoplasmic reticulum. Ver explicação completa e trilha adaptativa →