A 58-year-old man with type 2 diabetes presents with anxiety, diaphoresis, and intense hunger 2 hours after taking glyburide. Vital signs show BP 118/76, HR 108, RR 16, temp 37.2°C, SpO2 98%. He consumes a glucose-containing health food bar. Laboratory testing reveals serum glucose of 42 mg/dL with normal C-peptide levels. He denies recent alcohol use. Which of the following is most likely required to initiate energy production from the ingested glucose?

1. A)Phosphofructokinase
2. B)HexokinaseGABARITO
3. C)Pyruvate kinase
4. D)Phosphoglucose isomerase
5. E)Aldolase