A 35-year-old woman presents with palpitations, heat intolerance, and tremor for 3 months. Vital signs show HR 105 bpm, BP 138/72 mmHg, RR 18/min, temp 37.2°C. She denies recent neck pain or radioactive iodine exposure. Laboratory studies reveal suppressed TSH at 0.05 mIU/L and elevated free T4 at 2.8 ng/dL. A researcher identifies immunoglobulins that activate adenylate cyclase in thyroid follicular cells, driving excess thyroid hormone production. Which condition is most strongly associated with these antibodies?
- A)Secondary hypothyroidism
- B)Hashimoto thyroiditis
- C)Graves diseaseGABARITO
- D)Subacute thyroiditis
- E)Medullary thyroid carcinoma
Explicação
Graves disease is caused by thyroid stimulating immunoglobulins that bind and activate the TSH receptor, increasing cAMP. Ver explicação completa e trilha adaptativa →