A 24 year old woman with cystic fibrosis is admitted for worsening cough, fever, and increased sputum production. Sputum culture grows an oxidase positive gram negative rod that produces blue green pigment and has a fruity odor. Which of the following virulence mechanisms is most closely associated with severe tissue necrosis caused by this organism?
- A)Preformed heat stable toxin activation of guanylate cyclase
- B)Superantigen activation of T lymphocytes
- C)Cleavage of 28S ribosomal RNA
- D)ADP ribosylation of elongation factor 2GABARITO
- E)Inactivation of Rho GTPases
Explicação
ADP ribosylation of elongation factor 2 is correct. Pseudomonas aeruginosa exotoxin A inhibits protein synthesis and contributes to tissue destruction in severe infection. The cystic fibrosis history, fruity odor, and blue green pigment identify the organism. Ver explicação completa e trilha adaptativa →