A 36-year-old man with HIV presents with progressive lower extremity edema and dyspnea. Vital signs: BP 128/82 mmHg, HR 98/min, RR 20/min, Temp 37.2°C, SpO2 98% on room air. Laboratory studies reveal albumin 2.1 g/dL, proteinuria 4.2 g/24 hours, and serum creatinine 1.1 mg/dL. Urinalysis shows no hematuria. Renal biopsy demonstrates focal and segmental glomerulosclerosis with hyaline deposits on light microscopy. Which of the following is the most likely diagnosis?
- A)Minimal change disease
- B)Diabetic nephropathy
- C)Amyloidosis
- D)Membranous nephropathy
- E)Focal segmental glomerulosclerosisGABARITO
Explicação
Focal segmental glomerulosclerosis is a common cause of nephrotic syndrome in adults and is strongly associated with HIV infection, heroin use, obesity, and sickle cell disease. It features sclerosis involving some glomeruli and only parts of affected glomerul... Ver explicação completa e trilha adaptativa →