A 7-year-old girl develops progressive ascending weakness over 2 days while camping in the summer. Reflexes are decreased. She is afebrile, and CSF protein is normal. Careful skin examination reveals an engorged tick at the scalp line. Removal of the tick leads to improvement. Which of the following best explains this disorder?
- A)Anterior horn cell degeneration from viral infection
- B)Postinfectious autoimmune demyelination
- C)Presynaptic blockade of acetylcholine release by tick toxinGABARITO
- D)Autoimmune destruction of acetylcholine receptors
- E)Mutation in PMP22
Explicação
Tick paralysis is caused by a neurotoxin that interferes with acetylcholine release, producing an ascending flaccid paralysis that can mimic Guillain-Barré syndrome. Rapid improvement after tick removal is a key distinguishing clue. Ver explicação completa e trilha adaptativa →