A 27-year-old woman presents with chronic mild jaundice noted on routine examination. Vital signs are stable: BP 118/76 mmHg, HR 82 bpm, RR 16/min, temp 37°C, SpO2 98%. Laboratory studies show conjugated hyperbilirubinemia of 3.2 mg/dL with normal alkaline phosphatase and transaminases. Abdominal ultrasound shows no biliary obstruction or cirrhosis. Liver biopsy reveals coarse brown-black pigment within hepatocytes. She takes no medications. Which diagnosis best explains these findings?
- A)Gilbert syndrome
- B)Primary biliary cholangitis
- C)Dubin-Johnson syndromeGABARITO
- D)Rotor syndrome with black liver pigmentation
- E)Crigler-Najjar syndrome
Explicação
Dubin-Johnson syndrome is a benign inherited defect in hepatocellular excretion of conjugated bilirubin with characteristic dark liver pigment. Ver explicação completa e trilha adaptativa →