A 47-year-old woman with metastatic breast cancer who is undergoing chemotherapy comes to the physician for a follow-up exam. She reports extreme fatigue since beginning her chemotherapy regimen. Her pulse is 98/min, respirations are 16/min, and blood pressure is 132/84 mm Hg. Her hemoglobin is 10.4 g/dL, leukocyte count is 800/mm³ with 5% monocytes, and platelet count is 50,000/mm³. The patient is started on a new medication. One week later, serum studies show a hemoglobin of 10.6 g/dL, a leukocyte count of 2,000/mm³ with 2% monocytes, and a platelet count of 56,000/mm³. Which of the following drugs is the most likely cause of these findings?
- A)Aldesleukin
- B)Interferon beta
- C)FilgrastimGABARITO
- D)Romiplostim
- E)Sargramostim
Explicação
Filgrastim (recombinant G-CSF) stimulates common myeloid progenitors to differentiate into myeloblasts and then into neutrophils and basophils. Unlike GM-CSF (sargramostim), G-CSF does NOT promote differentiation into monocytes or eosinophils. This explains wh... Ver explicação completa e trilha adaptativa →