A 14-year-old boy presents with recurrent acute pancreatitis. Vital signs show BP 118/76 mmHg, HR 92 bpm, RR 18, temperature 37.2°C, SpO2 98% on room air. Fasting serum appears milky. Laboratory studies reveal serum triglycerides of 1,850 mg/dL and amylase 285 U/L. Abdominal ultrasound shows no gallstones. Genetic testing demonstrates normal lipoprotein lipase structure but impaired enzyme activation. Which apolipoprotein is most likely deficient?
- A)Apolipoprotein B100
- B)Apolipoprotein CIIGABARITO
- C)Apolipoprotein B48
- D)Apolipoprotein A1
- E)Apolipoprotein E
Explicação
Apolipoprotein CII is the required activator of lipoprotein lipase. Deficiency causes failure to hydrolyze triglycerides in chylomicrons and VLDL, leading to hypertriglyceridemia and pancreatitis despite an intact enzyme protein. The stem explicitly tells you ... Ver explicação completa e trilha adaptativa →