A 14-year-old boy presents with polyuria and polydipsia following a traumatic brain injury sustained in a motor vehicle accident three days ago. Vital signs show HR 92 bpm, BP 118/76 mmHg, RR 16, temp 37°C. Physical examination reveals dry mucous membranes. Serum sodium is 148 mEq/L, serum osmolality is 305 mOsm/kg, and urine osmolality is 210 mOsm/kg. Water deprivation testing shows minimal change in urine osmolality. However, after administering an intranasal ADH analog at a dose of 10 mcg, urine osmolality increases substantially to 580 mOsm/kg. No hyperglycemia is present. Which drug was administered?
- A)Hydrocortisone
- B)DesmopressinGABARITO
- C)Tolvaptan
- D)Demeclocycline
- E)Oxytocin
Explicação
Desmopressin is an ADH analog used in central diabetes insipidus and produces a marked increase in urine osmolality when ADH deficiency is the cause. It is also used in von Willebrand disease and mild hemophilia A because it increases release of vWF and factor... Ver explicação completa e trilha adaptativa →