A 45-year-old woman with chronic migraines (BP 128/82, HR 82, previously on topiramate) enrolls in a crossover trial comparing two prophylactic medications. After completing the first 8-week treatment phase with Drug A, she discontinues all study medication for 3 weeks before beginning Drug B. Headache frequency remains stable during the washout period. Which of the following is the primary reason for this mandatory interval between treatment phases?
- A)Improve specificity of the primary endpoint
- B)Prevent carryover effects from the first treatmentGABARITO
- C)Decrease type I error
- D)Increase allocation concealment
- E)Reduce attrition bias
Explicação
A washout period in a cross over trial is used to minimize carryover effects from the first intervention before the participant receives the second. Without it, lingering drug action could contaminate outcome measurement in the second period. This is especiall... Ver explicação completa e trilha adaptativa →