A 32-year-old man presents with fever (38.5°C), fatigue, and generalized lymphadenopathy. CD4+ count is 450 cells/μL with detectable viral load of 85,000 copies/mL. He denies opportunistic infections. A researcher studying his viral isolate notes it carries reverse transcriptase and integrates a DNA copy into host chromosomal DNA. Which enzyme is required after reverse transcription for stable viral persistence within his infected cells?
- A)Protease inhibitor from the host
- B)RNA dependent RNA polymerase
- C)DNA dependent RNA polymerase
- D)Neuraminidase
- E)IntegraseGABARITO
Explicação
Retroviruses reverse transcribe their RNA genome into DNA and then use viral integrase to insert that DNA into the host genome. Stable integration is essential for long term persistence and viral gene expression. Ver explicação completa e trilha adaptativa →