A 7-year-old boy develops acute swelling of his face and extremities after eating shellfish. Within 15 minutes, he becomes short of breath with audible wheezing. His tongue is swollen and he has difficulty swallowing. Which of the following mediators is primarily responsible for the acute airway obstruction in this patient?
- A)Leukotriene C4 produced by eosinophils
- B)Histamine released from mast cell degranulationGABARITO
- C)Tumor necrosis factor-alpha (TNF-α) from macrophage activation
- D)Complement component C5a generated by immune complex formation
- E)Bradykinin released from activated Hageman factor
Explicação
This is an acute IgE-mediated Type I hypersensitivity reaction (anaphylaxis). Mast cells degranulate rapidly upon allergen cross-linking of IgE, releasing histamine, which causes smooth muscle contraction, increased vascular permeability, and mucosal edema—pro... Ver explicação completa e trilha adaptativa →