A 2-year-old boy presents to the emergency department with gross hematuria and a palpable right abdominal mass. Vital signs reveal blood pressure of 128/82 mmHg (>95th percentile for age). Imaging confirms a large right renal tumor. Pathology shows a heterogeneous mass containing primitive mesenchymal elements including smooth muscle, striated muscle, bone, cartilage, adipose tissue, and areas of hemorrhagic necrosis. Which of the following chromosomal locations harbors the gene responsible for this condition?
- A)Chromosome 5 (APC gene)
- B)Chromosome 9 (CDKN2A gene)
- C)Chromosome 11 (WT1 gene)GABARITO
- D)Chromosome 13 (RB1 gene)
- E)Chromosome 17 (TP53 gene)
Explicação
Wilms tumor (nephroblastoma) is the most common renal malignancy in children and arises from embryonic renal tissue. The characteristic pathologic finding is a triphasic tumor containing blastema, epithelial, and stromal components (including muscle, bone, car... Ver explicação completa e trilha adaptativa →