A 27-year-old man presents with hemoptysis and cola-colored urine. Vital signs show BP 145/92 mmHg, HR 98 bpm, RR 22, temp 37.2°C, SpO2 94% on room air. Chest X-ray demonstrates diffuse bilateral alveolar infiltrates. Urinalysis reveals dysmorphic RBCs with RBC casts; urine protein 2.8 g/24 hours. Serum creatinine is 2.1 mg/dL. He denies recent upper respiratory infection. Which immunofluorescence pattern on renal biopsy is most likely?
- A)Linear IgG deposition along the glomerular basement membraneGABARITO
- B)Subepithelial granular immune deposits
- C)No immune deposits on immunofluorescence
- D)Congo red-positive fibrils
- E)Granular mesangial IgA deposition
Explicação
Goodpasture syndrome is caused by antibodies against the alpha-3 chain of type IV collagen in glomerular and alveolar basement membranes. The classic biopsy finding is linear IgG deposition along the glomerular basement membrane with pulmonary hemorrhage and r... Ver explicação completa e trilha adaptativa →