A 47-year-old man presents with a 3-month history of fatigue, early satiety, and 12-lb unintentional weight loss. Vital signs: BP 138/82, HR 102, RR 18, Temp 37.2°C, SpO2 98% on room air. Examination reveals marked splenomegaly; lymph nodes are not palpable. CBC shows WBC 185,000/μL with increased mature granulocytes and basophils. Philadelphia chromosome t(9;22) is identified on cytogenetics. Which pathogenic consequence results from this translocation?
- A)Overexpression of an antiapoptotic mitochondrial protein
- B)Amplification of a membrane growth factor receptor
- C)Constitutive activation of a tyrosine kinaseGABARITO
- D)Inactivation of a DNA mismatch repair protein
- E)Loss of the G1 to S checkpoint regulator RB
Explicação
The Philadelphia chromosome creates the BCR ABL fusion protein, a constitutively active tyrosine kinase that drives chronic myelogenous leukemia. The massive granulocytic proliferation with basophilia and splenomegaly is classic for this disorder. Ver explicação completa e trilha adaptativa →