A 35-year-old woman with a known pituitary adenoma undergoes surgery. Histologic examination of the resected tissue reveals polygonal cells with eccentric nuclei and basophilic cytoplasm organized in nests separated by a rich vascular network. The cells stain positive for growth hormone. Which of the following histologic features is most consistent with this diagnosis?
- A)Spindle cells with fascicular arrangement and palisading nuclei
- B)Squamous metaplasia with keratinization and inflammatory infiltrate
- C)Clear cells with lipid content and trabecular organization
- D)Follicular arrangement with colloid material and sparse vascularization
- E)Somatotroph cells with basophilic cytoplasm and perivascular arrangementGABARITO
Explicação
Growth hormone-secreting adenomas (somatotroph adenomas) are composed of polygonal somatotroph cells with basophilic (acidophilic/eosinophilic) cytoplasm due to abundant rough endoplasmic reticulum. They are organized around a rich sinusoidal vascular network ... Ver explicação completa e trilha adaptativa →