A 45-year-old man presents with eruptive xanthomas, hepatosplenomegaly, and recurrent pancreatitis. Vital signs show BP 138/82 mmHg, HR 88/min, RR 16/min, temp 37.2°C. Serum triglycerides are 2,800 mg/dL with normal cholesterol levels. Abdominal ultrasound reveals pancreatic edema. He denies alcohol use. Family history is significant for similar lipid abnormalities. Genetic testing confirms a mutation in lipoprotein lipase. Which of the following best explains the accumulation of triglyceride-rich lipoproteins in this patient?
- A)Reduced clearance of HDL by hepatic lipase
- B)Impaired hydrolysis of chylomicron and VLDL triglyceridesGABARITO
- C)Increased enterocyte absorption of dietary cholesterol
- D)Decreased hepatic synthesis of apolipoprotein B-100
- E)Enhanced conversion of VLDL to LDL in circulation
Explicação
Lipoprotein lipase is essential for hydrolyzing triglycerides in chylomicrons and VLDL at the capillary endothelium. Loss of function causes dramatic accumulation of these triglyceride-rich particles, leading to Type I hyperlipoproteinemia. Ver explicação completa e trilha adaptativa →