A 48-year-old woman presents with progressive bilateral leg edema and dyspnea on exertion. Vital signs show BP 148/92 mmHg, HR 88/min, RR 18/min, temp 37°C, SpO2 98% on room air. Urinalysis reveals nephrotic-range proteinuria (8.5 g/24h). Serum albumin is 2.1 g/dL. Anti-phospholipase A2 receptor antibodies are positive. She denies hematuria. Which renal biopsy finding is most likely present?
- A)Wire-loop lesions with anti-dsDNA antibodies
- B)Linear IgG deposition along the basement membrane
- C)Diffuse foot process effacement with normal light microscopy
- D)Mesangial IgA deposition
- E)Subepithelial immune complex deposits with spike and dome appearanceGABARITO
Explicação
Primary membranous nephropathy is strongly associated with antibodies to the phospholipase A2 receptor on podocytes. Renal biopsy typically shows diffuse capillary wall thickening and subepithelial immune complex deposits producing a spike-and-dome appearance ... Ver explicação completa e trilha adaptativa →