A 19 year old college student develops cola colored urine 1 day after the onset of sore throat and fever. He has had two similar episodes after respiratory infections in the past. Blood pressure and kidney function are normal. Which of the following is the most likely underlying mechanism of this patient's renal disease?
- A)Granular deposition of DNA anti DNA immune complexes with low complement
- B)Subepithelial deposition of immune complexes after streptococcal skin infection
- C)Mesangial deposition of aberrantly glycosylated IgA containing immune complexesGABARITO
- D)Nephrin mutation causing loss of slit diaphragm integrity
- E)Antibodies directed against type IV collagen in the basement membrane
Explicação
IgA nephropathy classically causes recurrent gross hematuria that occurs at the same time as or within a day or two of a mucosal infection. The pathophysiology is mesangial deposition of IgA based immune complexes, often involving abnormally glycosylated IgA1. Ver explicação completa e trilha adaptativa →