A 23-year-old woman with hypermobile joints and translucent skin presents with palpitations. Vital signs: BP 118/76 mmHg, HR 92/min, RR 16/min, SpO2 98% on room air. Cardiac examination reveals a midsystolic click and late systolic murmur at the apex. Echocardiography shows mitral valve leaflet prolapse with mild regurgitation. She denies orthopnea. Which histopathologic change most likely underlies her valvular abnormality?
- A)Calcific nodules with commissural fusion
- B)Noncaseating granulomas in the valve cusp
- C)Fibrinoid necrosis of the valve annulus
- D)Myxomatous degeneration with accumulation of proteoglycansGABARITO
- E)Caseating granulomatous inflammation
Explicação
Mitral valve prolapse is caused by myxomatous degeneration of the valve, with expansion of the spongiosa and accumulation of proteoglycan rich material. It is associated with connective tissue disorders such as Marfan and Ehlers Danlos syndromes. The physical ... Ver explicação completa e trilha adaptativa →