A 26-year-old woman at 8 weeks' gestation presents with palpitations, heat intolerance, and weight loss. Vital signs show BP 138/82 mmHg, HR 108 bpm, RR 18/min, and temperature 37.8°C. Laboratory studies reveal suppressed TSH at 0.08 mIU/L and elevated free T4 at 3.2 ng/dL. Thyroid ultrasound demonstrates diffuse gland enlargement. She denies prior antithyroid medication use. Given the critical pregnancy stage, her physician selects a thionamide that also inhibits peripheral conversion of T4 to T3. Which drug was prescribed?
- A)Potassium iodide
- B)Methimazole
- C)Radioactive iodine
- D)PropylthiouracilGABARITO
- E)Propranolol
Explicação
Propylthiouracil is preferred during the first trimester because methimazole is teratogenic. PTU also inhibits peripheral 5 prime deiodinase, so it decreases conversion of T4 to T3 in addition to blocking thyroid hormone synthesis. Ver explicação completa e trilha adaptativa →