A 52-year-old man with central obesity, hypertension, and acanthosis nigricans presents with polyuria and polydipsia. Vital signs show BP 148/92 mmHg, HR 88/min, RR 16/min, temperature 37°C, and SpO2 98% on room air. Laboratory studies reveal hemoglobin A1c of 9.2% and fasting glucose of 256 mg/dL. Urinalysis shows no ketones. Early in the course of his disease, which of the following laboratory findings is most likely?
- A)Absent C peptide due to autoimmune beta cell destruction
- B)High anti glutamic acid decarboxylase antibodies and low insulin
- C)Low glucagon due to alpha cell failure
- D)Severe ketonemia due to absolute insulin deficiency
- E)Elevated C peptide with peripheral insulin resistanceGABARITO
Explicação
Type 2 diabetes begins with peripheral insulin resistance, especially in muscle and liver, and the pancreas initially compensates by secreting more insulin. Therefore endogenous insulin and C peptide are often elevated early in disease. Obesity and acanthosis ... Ver explicação completa e trilha adaptativa →