A 67-year-old man with peripheral vascular disease presents with chest discomfort. Vital signs: BP 158/92 mmHg, HR 88 bpm, RR 16, SpO2 98% on room air. He takes high-dose simvastatin. Labs show LDL cholesterol 95 mg/dL, lipoprotein(a) 85 nmol/L (normal <50), and normal triglycerides at 120 mg/dL. Troponin is negative. Despite achieving LDL goals, which lipoprotein fraction best explains his persistent cardiovascular risk?
- A)Lipoprotein(a) has proatherogenic and prothrombotic properties independent of LDL-CGABARITO
- B)Lipoprotein(a) increases hepatic cholesterol synthesis by feedback inhibition
- C)Lipoprotein(a) is primarily composed of free cholesterol that cannot be measured by standard lipid panels
- D)High lipoprotein(a) directly reduces lipoprotein lipase activity
- E)Elevated lipoprotein(a) inhibits the anticoagulant effects of statins
Explicação
Lipoprotein(a) [Lp(a)] is an independent risk factor for atherosclerotic cardiovascular disease, carrying an ApoB-100 particle with an additional ApoA moiety structurally similar to plasminogen. It has intrinsic proatherogenic properties (inflammation, endothe... Ver explicação completa e trilha adaptativa →