A 35-year-old woman has progressive exertional dyspnea, fatigue, and one episode of syncope while climbing stairs. Examination shows a loud P2 and signs of right ventricular strain. Right heart catheterization shows mean pulmonary artery pressure 32 mm Hg, elevated pulmonary vascular resistance, and normal pulmonary capillary wedge pressure. Which of the following medications directly antagonizes endothelin mediated vasoconstriction in this condition?
- A)BosentanGABARITO
- B)Fluticasone
- C)Montelukast
- D)Ipratropium
- E)Roflumilast
Explicação
This patient has precapillary pulmonary arterial hypertension, which can be idiopathic or associated with BMPR2 pathway abnormalities. Bosentan is an endothelin receptor antagonist that reduces pulmonary vasoconstriction and vascular remodeling. Normal wedge p... Ver explicação completa e trilha adaptativa →