A 59 year old man with an acute myocardial infarction undergoes successful percutaneous coronary intervention 45 minutes after symptom onset. Initially his chest pain improves, but biomarker release rises sharply over the next several hours. Additional injury after restoration of blood flow is thought to be due in part to which of the following mechanisms?
- A)Immediate replacement by granulation tissue
- B)Decreased intracellular calcium concentration
- C)Upregulation of BCL2 and inhibition of caspases
- D)Generation of oxygen derived free radicalsGABARITO
- E)Suppression of neutrophil adhesion molecules
Explicação
Reperfusion injury occurs when restoration of blood flow paradoxically amplifies damage through reactive oxygen species generation, calcium influx, inflammation, and mitochondrial permeability changes. In the setting of acute myocardial reperfusion, oxygen der... Ver explicação completa e trilha adaptativa →