A 70-year-old man with acute decompensated heart failure presents with dyspnea, orthopnea, and bilateral ankle edema. Vital signs show BP 165/95 mmHg, HR 102 bpm, RR 22/min, temp 37.2°C, SpO2 92% on room air. Chest X-ray reveals pulmonary edema. BNP is elevated at 850 pg/mL. He receives intravenous furosemide and rapidly produces 2 liters of urine within 2 hours. Troponin is normal. Which transporter system is directly inhibited by this medication?
- A)Na K 2Cl cotransporter in the thick ascending limbGABARITO
- B)Na Cl cotransporter in the distal convoluted tubule
- C)Sodium glucose cotransporter in the proximal tubule
- D)Epithelial sodium channel in the collecting duct
- E)Carbonic anhydrase in the proximal tubule
Explicação
Loop diuretics such as furosemide block the Na K 2Cl cotransporter in the thick ascending limb of the loop of Henle. This causes powerful natriuresis and diuresis, making them useful in pulmonary edema and volume overload. Ver explicação completa e trilha adaptativa →