A 62-year-old man with benign prostatic hyperplasia presents with progressive urinary hesitancy, weak stream, and incomplete bladder emptying over 6 months. His blood pressure is 138/86 mmHg and heart rate is 64 beats per minute. Current medications include lisinopril 10 mg daily and atenolol 50 mg daily. Digital rectal examination reveals a uniformly enlarged prostate (45 grams). Post-void residual volume is 95 mL. The urologist prescribes an alpha-1A-selective antagonist (tamsulosin) rather than a non-selective alpha-1 antagonist (terazosin). Which of the following best explains the pharmacologic basis for preferring the alpha-1A-selective agent in this patient?

1. A)Alpha-1A receptors have greater tissue penetration due to higher lipophilicity in prostatic tissue compared to vascular endothelium
2. B)Alpha-1A receptors predominate in prostatic smooth muscle, whereas alpha-1B receptors mediate vasoconstriction in systemic blood vesselsGABARITO
3. C)Alpha-1A-selective antagonists undergo hepatic metabolism that inactivates the drug preferentially in vascular beds through first-pass metabolism
4. D)The prostate expresses alpha-1 receptors with higher affinity for antagonists than vascular smooth muscle, allowing selective blockade at lower doses
5. E)Alpha-1A receptors in the prostate have a lower threshold for activation, allowing therapeutic effects at doses that cause minimal vascular effects