A 39-year-old woman with Cushing disease presents for pituitary ACTH reserve testing. Vital signs show BP 148/92, HR 88, RR 14, Temp 37°C. She has central obesity and proximal muscle weakness but denies headaches. Baseline cortisol is 32 mcg/dL (elevated). A drug inhibiting 11β-hydroxylase is administered, causing cortisol to decrease and 11-deoxycortisol to increase substantially. She takes no prior medications. Which drug was most likely administered?
- A)Hydrocortisone
- B)MetyraponeGABARITO
- C)Fludrocortisone
- D)Ketoconazole
- E)Radioactive iodine
Explicação
Metyrapone inhibits 11 beta hydroxylase and lowers cortisol synthesis, causing accumulation of 11-deoxycortisol. It is used diagnostically and therapeutically in hypercortisolism, and androgen precursor buildup can produce hirsutism. Ver explicação completa e trilha adaptativa →