A 31 year old woman presents with unilateral leg swelling 2 weeks after starting an estrogen containing oral contraceptive. Her mother had multiple deep venous thromboses. Coagulation studies are normal. Genetic testing reveals a mutation that makes factor V resistant to inactivation. Which of the following proteins normally inactivates factor V?
- A)Factor VII
- B)Antithrombin
- C)Plasmin
- D)Von Willebrand factor
- E)Activated protein CGABARITO
Explicação
Activated protein C is correct. Factor V Leiden is the most common inherited thrombophilia and results from resistance of factor V to cleavage by activated protein C. Estrogen exposure further increases thrombotic risk, making venous thrombosis a classic prese... Ver explicação completa e trilha adaptativa →