A 45-year-old woman with central obesity, proximal muscle weakness, and easy bruising undergoes evaluation for Cushing syndrome. Vital signs show BP 158/92 mmHg, HR 88 bpm, RR 16/min, temp 37.2°C. Laboratory studies reveal 24-hour urinary free cortisol 250 mcg (normal <50), with morning ACTH 35 pg/mL. An exogenous glucocorticoid is administered overnight, and serum cortisol is measured the following morning to assess suppression of ACTH-driven endogenous cortisol production. Which drug is most appropriate for this diagnostic test?
- A)Ketoconazole
- B)DexamethasoneGABARITO
- C)Hydrocortisone
- D)Mifepristone
- E)Fludrocortisone
Explicação
Dexamethasone is used in suppression testing because it is a potent glucocorticoid with minimal mineralocorticoid activity and provides reliable feedback suppression. It is the classic drug used in the dexamethasone suppression test for hypercortisolism. Ver explicação completa e trilha adaptativa →