A 45-year-old man with diabetes mellitus type 2 presents with recurrent pancreatitis. Laboratory studies show triglycerides of 1,200 mg/dL and total cholesterol of 680 mg/dL. His father died of myocardial infarction at age 52. Genetic testing reveals a mutation in the lipoprotein lipase gene. Which of the following pathways is primarily impaired in this patient?
- A)Synthesis of apolipoprotein B-100 in hepatocytes
- B)Uptake of LDL particles via LDL receptor-mediated endocytosis
- C)Hydrolysis of triglycerides in chylomicrons and VLDL by lipoprotein lipaseGABARITO
- D)Esterification of cholesterol in HDL by LCAT
- E)Conversion of VLDL to IDL by hepatic triglyceride lipase
Explicação
Lipoprotein lipase (LPL) deficiency causes Type I hyperlipoproteinemia with severe hypertriglyceridemia due to accumulation of chylomicrons and VLDL. LPL is the enzyme responsible for hydrolysis of triglycerides in these lipoproteins at the capillary endotheli... Ver explicação completa e trilha adaptativa →