A 44-year-old man with an unprovoked deep vein thrombosis and subsequent pulmonary embolism is found to have a Factor V Leiden mutation on hypercoagulability testing. He is heterozygous for the mutation. He has been on anticoagulation for 6 months. Which of the following best describes the implication of this finding for his long-term management?
- A)Anticoagulation can be safely stopped at 6 months because heterozygous Factor V Leiden carries low recurrence risk
- B)Test all first-degree relatives and anticoagulate those who are positive
- C)Switch to aspirin for lifelong secondary prevention
- D)The Factor V Leiden mutation does not affect management decisions for VTE
- E)Indefinite anticoagulation is recommended given the combination of unprovoked VTE and thrombophiliaGABARITO
Explicação
Unprovoked VTE in a patient with a confirmed thrombophilia (heterozygous Factor V Leiden) favors indefinite anticoagulation because both the unprovoked nature and the genetic predisposition increase recurrence risk. Current guidelines recommend extended antico... Ver explicação completa e trilha adaptativa →