A 59 year old man with hypertension forgot to refill one of his medications and stopped it abruptly 2 days ago. He now presents with severe headache, agitation, blood pressure of 214/118 mm Hg, and heart rate of 112 per minute. The missing drug normally reduces sympathetic outflow by stimulating presynaptic receptors in the brainstem. Sudden discontinuation of which of the following medications most likely caused this presentation?
- A)Nitroglycerin
- B)ClonidineGABARITO
- C)Lisinopril
- D)Amlodipine
- E)Hydrochlorothiazide
Explicação
Clonidine is a central alpha 2 agonist that lowers sympathetic outflow. Abrupt withdrawal can produce rebound hypertension because chronic suppression is removed and adrenergic activity surges. Ver explicação completa e trilha adaptativa →