A 5-year-old boy presents with progressive difficulty climbing stairs and frequent falls over the past 6 months. He uses his hands to push himself upright from the floor (Gowers sign). Vital signs: HR 98/min, BP 105/68 mmHg, RR 20/min, Temp 37°C. Physical examination reveals calf pseudohypertrophy bilaterally and proximal lower extremity weakness. Serum creatine kinase is elevated at 8,500 U/L. No cardiac arrhythmias noted on examination. Which diagnosis best explains these findings?

  1. A)Inclusion body myositis
  2. B)Myotonic dystrophy
  3. C)Duchenne muscular dystrophyGABARITO
  4. D)Becker muscular dystrophy
  5. E)Myasthenia gravis

Explicação

Duchenne muscular dystrophy presents in early childhood with proximal muscle weakness, Gowers maneuver, and calf pseudohypertrophy. It is caused by absence of dystrophin due to an X linked frameshift mutation. Ver explicação completa e trilha adaptativa →

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