A 46-year-old man presents with progressive hand and jaw enlargement, frontal headaches, and visual field defects. Vital signs show BP 158/92 mmHg, HR 88/min, RR 16/min, temperature 37.2°C. Examination reveals coarse facial features, prognathism, and bitemporal hemianopia. Fasting glucose is 156 mg/dL. MRI demonstrates a 2-cm sellar mass. No galactorrhea or amenorrhea noted. Which pituitary cell type is most likely undergoing neoplastic proliferation?
- A)SomatotrophsGABARITO
- B)Thyrotrophs
- C)Corticotrophs
- D)Lactotrophs
- E)Gonadotrophs
Explicação
This patient has acromegaly with mass effect from a pituitary macroadenoma. Growth hormone is produced by somatotrophs of the anterior pituitary and causes elevated IGF 1, soft tissue overgrowth, insulin resistance, and enlargement of hands, feet, and jaw. The... Ver explicação completa e trilha adaptativa →