A 28-year-old woman with known pyruvate kinase deficiency presents with fatigue and jaundice. Vital signs show BP 118/76, HR 102, RR 18, Temp 37.2°C, SpO2 98%. Laboratory studies reveal hemoglobin 8.2 g/dL, reticulocyte count 12%, and elevated indirect bilirubin at 3.1 mg/dL. Peripheral blood smear shows spherocytes. She denies abdominal pain or dark urine. A third-year medical student recognizes this hemolytic presentation and must identify which disease demonstrates the most similar pathophysiologic mechanism.

1. A)Glucose-6-phosphate dehydrogenase deficiencyGABARITO
2. B)β-Thalassemia
3. C)Iron deficiency anemia
4. D)Hereditary spherocytosis
5. E)α-Thalassemia