A 58-year-old man with a 40-pack-year smoking history presents with progressive dyspnea on exertion and difficulty climbing stairs. Vital signs show BP 142/88 mmHg, HR 102 bpm, RR 24/min, and SpO2 88% on room air. Physical examination reveals proximal muscle weakness that paradoxically improves with repeated contractions. Chest CT demonstrates a central hilar mass. Recent labs show elevated creatine kinase. He denies diplopia or ptosis. Which of the following is the most likely diagnosis?
- A)Pancoast tumor
- B)Adenocarcinoma
- C)Small cell carcinomaGABARITO
- D)Mesothelioma
- E)Squamous cell carcinoma
Explicação
Small cell lung carcinoma is a central neuroendocrine tumor strongly associated with smoking. It commonly causes paraneoplastic syndromes, including Lambert Eaton myasthenic syndrome due to antibodies against presynaptic calcium channels. Improvement in streng... Ver explicação completa e trilha adaptativa →