A 10-year prospective cohort study enrolls 10,000 current smokers (mean age 55, smoking ≥1 pack daily for ≥30 years) and 10,000 age-matched never-smokers to assess lung cancer risk. At baseline, spirometry shows FEV1/FVC ratio of 0.68 in smokers versus 0.82 in never-smokers. During the 10-year follow-up period, 200 smokers are diagnosed with histologically-confirmed lung adenocarcinoma compared to 20 never-smokers. Occupational asbestos and radon exposure are similar between groups. Which of the following best represents the relative risk of lung cancer in smokers compared to never-smokers?

  1. A)0.1
  2. B)1.8
  3. C)10.0GABARITO
  4. D)18.0
  5. E)20.0

Explicação

Relative risk (RR) is calculated as the risk (incidence rate) in the exposed group divided by the risk in the unexposed group. Risk in smokers = 200/10,000 = 0.02 or 2%. Risk in never-smokers = 20/10,000 = 0.002 or 0.2%. Therefore, RR = 0.02/0.002 = 10.0. This... Ver explicação completa e trilha adaptativa →

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