A 28-year-old woman presents to the hematology clinic for evaluation of recurrent thromboembolism. She has a history of two unprovoked deep vein thromboses at ages 24 and 26, and two consecutive first-trimester miscarriages. Physical examination is unremarkable. Laboratory studies show: PT: 12 seconds (normal: 11-13.5) aPTT: 38 seconds (normal: 25-35) aPTT after mixing with normal plasma: 36 seconds Lupus anticoagulant: Positive Anticardiolipin IgG antibodies: 45 GPL units (elevated; normal <15) Anti-β2 glycoprotein I antibodies: Negative Protein C activity: Normal Factor V Leiden mutation: Negative Prothrombin G20210A mutation: Negative Which of the following is the most likely diagnosis?
- A)Protein C deficiency
- B)Factor V Leiden heterozygosity
- C)Prothrombin G20210A mutation
- D)Isolated systemic lupus erythematosus without antiphospholipid antibodies
- E)Antiphospholipid syndromeGABARITO
Explicação
Antiphospholipid syndrome (APS) is characterized by thrombosis and/or pregnancy morbidity in the setting of persistently positive antiphospholipid antibodies (lupus anticoagulant, anticardiolipin antibodies, or anti-β2 glycoprotein I antibodies). This patient ... Ver explicação completa e trilha adaptativa →