A 26-year-old man with no significant past medical history presents with acute kidney injury, hematuria with dysmorphic RBCs and RBC casts, and mild hypertension. He denies recent URI. Renal biopsy shows crescents in >50% of glomeruli with fibrinoid necrosis. ANCA and anti-GBM antibodies are both negative. Which of the following is the most likely diagnosis?
- A)Anti-GBM disease
- B)Lupus nephritis Class IV
- C)ANCA-associated vasculitis
- D)ANCA-negative pauci-immune crescentic GNGABARITO
- E)Post-infectious glomerulonephritis
Explicação
ANCA-negative pauci-immune crescentic GN accounts for 10% of rapidly progressive GN cases. It presents with acute nephritis, crescents on biopsy, and minimal or no immune deposits on immunofluorescence, with negative ANCA and anti-GBM. It requires urgent immun... Ver explicação completa e trilha adaptativa →