A 26-year-old African American man comes to the physician because of a 3-day history of fatigue, back pain, and dark urine. One week ago, he developed a headache and was treated with aspirin. He does not smoke or use illicit drugs. Physical examination shows conjunctival pallor. A peripheral blood smear shows erythrocytes with inclusions of denatured hemoglobin. Which of the following enzymes is essential for the production of nucleotides in this patient?
- A)Pyruvate carboxylase
- B)Carbamoyl phosphate synthetase I
- C)Enolase
- D)Glucose-6-phosphatase
- E)TransketolaseGABARITO
Explicação
This patient has G6PD deficiency (African American, hemolysis after aspirin, Heinz bodies on smear). G6PD catalyzes the rate-limiting step of the pentose phosphate pathway (PPP) oxidative branch, which normally produces ribose-5-phosphate (R5P) for nucleotide ... Ver explicação completa e trilha adaptativa →