A 19-year-old previously healthy man presents with acute bilateral leg pain, cyanosis of his feet, and gangrene developing within hours. Laboratory studies show a platelet count of 150,000/μL, PT 13 seconds, aPTT 38 seconds, and fibrinogen 280 mg/dL. He has no personal or family history of thrombosis. Which of the following is the most likely diagnosis?

  1. A)Antiphospholipid syndrome
  2. B)Factor V Leiden heterozygosity
  3. C)Prothrombin G20210A mutation
  4. D)Disseminated intravascular coagulation
  5. E)Protein C deficiency (acute phase)GABARITO

Explicação

Protein C deficiency, especially homozygous or compound heterozygous forms, causes neonatal purpura fulminans with massive thrombosis and skin necrosis. When warfarin is initiated without heparin overlap, it can precipitate acute protein C depletion and thromb... Ver explicação completa e trilha adaptativa →

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