A 65-year-old woman with a 10-year history of Parkinson disease on levodopa develops sudden fluctuations in motor control—periods of excellent mobility ('on' states) alternating with severe bradykinesia and rigidity ('off' states). The duration of benefit from each dose decreases despite escalating doses. Which of the following best describes this phenomenon?
- A)Levodopa-induced dyskinesia
- B)Motor fluctuations (wearing-off effect)GABARITO
- C)Neuroleptic malignant syndrome
- D)Disease progression resistant to medication
- E)Medication nonadherence
Explicação
Motor fluctuations, specifically the 'wearing-off' effect, develop after years of levodopa therapy due to loss of dopaminergic neurons and striatal degeneration. Patients experience shortened duration of benefit from each dose, creating predictable cycles of m... Ver explicação completa e trilha adaptativa →