A 46-year-old battery factory worker presents with acute wrist drop and foot drop. He reports abdominal pain, irritability, and constipation for 3 weeks. Vital signs: BP 148/92, HR 102, RR 18, Temp 37°C, SpO2 98%. Laboratory studies reveal microcytic anemia (Hgb 9.2 g/dL) with basophilic stippling on blood smear. Nerve conduction studies show slowed motor velocities. No cognitive changes noted. Which of the following is the most likely cause of his motor deficit?
- A)Lead induced motor neuropathy affecting radial nerve functionGABARITO
- B)Presynaptic calcium channel autoantibodies
- C)Postsynaptic receptor blockade at the neuromuscular junction
- D)Inherited demyelination due to PMP22 duplication
- E)Autoimmune destruction of anterior horn cells
Explicação
Lead toxicity can cause a motor neuropathy that classically presents with wrist or foot drop. The associated abdominal pain and basophilic stippling reinforce heavy metal exposure as the cause. Ver explicação completa e trilha adaptativa →