A 7-year-old boy presents with acute otitis media (BP 105/68, HR 98, RR 22, Temp 38.5°C). Otoscopy reveals erythematous tympanum with fluid level; tympanometry confirms type B pattern. He is prescribed amoxicillin and has no reported penicillin allergy. The drug exerts its antibacterial effect by binding penicillin-binding proteins and inhibiting peptidoglycan cross-linking in the bacterial cell wall. Which of the following best describes the consequence of this mechanism of action?
- A)Inhibition of 30S ribosomal translocation
- B)Disruption of ergosterol synthesis in fungal membranes
- C)Activation of autolytic enzymes leading to bacterial lysisGABARITO
- D)Blockade of folate synthesis through dihydropteroate synthase inhibition
- E)Creation of DNA strand breaks by free radicals
Explicação
Beta-lactam antibiotics bind penicillin-binding proteins, which are transpeptidases required for cross-linking peptidoglycan. This weakens the bacterial cell wall and promotes activation of autolysins, leading to osmotic lysis. The stem directly describes the ... Ver explicação completa e trilha adaptativa →